This issue is only occur in Windows 10.

This will happen again and again after your restart or shutdown windows 10 pc. So, your also much do same method again and over again to make sure Sage 50 work well. There is no end for this, as long  as you use windows 10 , this issue keep happen in future.  

To fix this your need to run Sage 50 and Mysql services. Follow step below : 

Make sure all Sage services is running.

Also make sure Mysql services is running.

To start it services , please follow step below :

Services starting to running. 

The services is successful running.

Do same step for the rest. 

Remainder : 

Make sure your start all Sage Services and Mysql services.